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KMID : 0604620070140010041
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Dongguk Journal of Medicine
2007 Volume.14 No. 1 p.41 ~ p.49
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Clinical Study of Kawasaki Disease in Gyeongju
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Jung Jae-Youl
Kim Ae-Suk
Lee Sun-Ju
Cho Sung-Min
Lee Dong-Seok
Kim Doo-Kwun
Choi Sung-Min
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Abstract
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From 1990, nationwide epidemologic studies of Kawasaki disease have been conducted every 3 years in Korea, yet no study has been reported from Gyeongju. We investigated epidemiology and clinical characteristics of Kawasaki disease in Gyeongju for 7 years. We retrospectively analyzed the medical records of 100 Kawasaki disease patients, admitted to the Dongguk University Hospital Pediatrics from January 1st, 2000 to December 31st 2006, based on clinical symptoms, laboratory findings and coronary artety complications by echocardiography. Male to female ratio was 1.7:1 and mean age was 32 months. There was no seasonal variation. Inciednces of typiacl and atypical Kawasaki disease were 83% and 17%, respectively. Inciednce of occurring symptoms were as follows; 93% of conjunctival injection; 93% of lip redness fissuring, tongue and oral erythema; 91% of amorphous skin rash; 80% of hand, foot erythema and edema; 52% of non-purulent cervical lymph node enlargement. For others, 46% of pyuria. 7% of coronary artery aneurysm was noted. Significant predictable risk factors for coronaty artery aneurysm were ALT(p=0.04), albumin(p=0.008), CRP(p=0.027), non-responsiveness to initial IVIG(intravenous immunoglobulin) treatment (p=0.001) and pyuria(p=0.046). 14% of patients were unresponsive to initial high dose IVIG traatment. Significant predictable risk factors for initial IVIG treatment failure were AST(p=0.019), ALT(p=0.003), ESR(p=0.017) and pyuria(p=0.047). The results of our study on epidemiologic and clinical characteristics of Kawasaki disease in Gyeongju were similar to other studies. Also, predictable risk factors of coronaty artery sneurysm and initial high dose IVIG treatment failute were as similar as in other studies.
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KEYWORD
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Kawasaki disease, intravenous immunoglobulin, Gyeongju
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